Pyrimidines And Derivatives
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Filtered Search Results
Medchemexpress LLC G-5555 | 1648863-90-4 | 99.9% | 492.96 | 250 MG
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G-5555 is a potent p21-activated kinase 1 (PAK1) inhibitor with Kis of 3.7 nM and 11 nM for PAK1 and PAK2, respectively. It is for research use only and not sold to patients.
- Is a potent PAK1 inhibitor with a Ki of 3.7 nM.
- Exhibits excellent kinase selectivity, inhibiting only eight out of 235 kinases tested other than PAK1 with >70% inhibition.
- Demonstrates high selectivity for group I PAKs.
- Has negligible activity against the hERG channel.
- Shows low blood clearance and an acceptable half-life with high oral bioavailability.
- Imparts 60% tumor growth inhibition in H292 non-small cell lung cancer xenograft studies at 25 mg/kg b.i.d.
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Medchemexpress LLC Methyl-β-cyclodextrin | 128446-36-6 | MFCD00074980 | 99.9% | 1303.3 g/mol | C54H94O35 | 100 G
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Methyl-β-cyclodextrin is a methylated derivative of β-cyclodextrin used to solubilize hydrophobic compounds and to deplete membrane cholesterol in biological research. It forms inclusion complexes with nonpolar molecules, improving aqueous solubility and facilitating delivery and uptake in cellular assays and formulations.
- Enhances solubility of hydrophobic molecules for biological and formulation studies.
- Depletes membrane cholesterol to enable mechanistic studies of membrane-dependent processes.
- Facilitates delivery of poorly soluble compounds in aqueous media.
- Modulates endocytosis pathways in cell-based assays.
- High purity supports reproducible experimental results.
- Available in multiple pack sizes to suit lab-scale needs.
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eMolecules 50270-27-4 | 2,4,6-Trichloro-5-pyrimidinecarboxaldehyde | Accela ChemBio (ASD) | MFCD02257700 | 211.430 | C5HCl3N2O | 97.000 | Clc1nc(Cl)c(C=O)c(Cl)n1 | 1g | 444745637
2,4,6-Trichloro-5-pyrimidinecarboxaldehyde | Accela ChemBio (ASD) | 50270-27-4 | MFCD02257700 | 211.430 | C5HCl3N2O | 97.000 | Clc1nc(Cl)c(C=O)c(Cl)n1 | 1g | 444745637
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Medchemexpress LLC 2'-O,4'-C-methyleneguanosine | 207131-16-6 | MFCD31707476 | 99.2% | 295.25 | C11H13N5O5 | 250 MG
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2'-O,4'-C-Methyleneguanosine is a locked nucleic acid (LNA) guanosine analogue used as a research reagent for oligonucleotide modification and nucleic acid chemistry. It is supplied as a high-purity chemical for laboratory use and is accompanied by documentation for quality and safe handling.
- Locked nucleic acid guanosine analogue for oligonucleotide modification.
- High chemical purity (99.2%).
- Suitable for nucleic acid chemistry and research applications (non-clinical).
- Available in multiple pack sizes for laboratory use.
- Certificate of analysis and safety data sheet available.
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eMolecules EMOLECULES INC
5000841537 C12-200 250MG
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eMolecules 898044-48-9 | 4-Chloropyrimidine-2-carbonitrile | Ambeed | MFCD09607718 | 139.540 | C5H2ClN3 | 98.000 | Clc1ccnc(n1)C#N | 1g | 575776843
4-Chloropyrimidine-2-carbonitrile | Ambeed | 898044-48-9 | MFCD09607718 | 139.540 | C5H2ClN3 | 98.000 | Clc1ccnc(n1)C#N | 1g | 575776843
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Medchemexpress LLC 5-fluoroorotic acid | 703-95-7 | MFCD00042526 | 99.4% | 174.09 g/mol | C5H3FN2O4 | 500 MG
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5-Fluoroorotic acid is a pyrimidine analog that inhibits thymidylate synthase and is used as a selective agent in yeast molecular genetics. It is provided for research use and has reported antimalarial activity.
- Thymidylate synthase inhibitor used in biochemical research.
- Selective agent for yeast genetics applications.
- Reported antimalarial activity documented in literature.
- Available in solid and solution formats for experimental flexibility.
- High purity suitable for analytical and biological assays.
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eMolecules 3849-21-6 | Ethyl cyano(hydroxyimino)acetate | Apollo Scientific US - Building Blocks | MFCD00002112 | 142.114 | C5H6N2O3 | 95.000 | CCOC(=O)C(=N\O)\C#N | 100g | 397998112
Ethyl cyano(hydroxyimino)acetate | Apollo Scientific US - Building Blocks | 3849-21-6 | MFCD00002112 | 142.114 | C5H6N2O3 | 95.000 | CCOC(=O)C(=N\O)\C#N | 100g | 397998112
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eMolecules EMOLECULES INC
5000492530 METHYL 4-FORMYLBENZOATE 100G
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Chemscene CHEMSCENE
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5000578679 2-CHLOROPYRIMIDINE 500G
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eMolecules 123131-67-9 | 2-(2,2-Difluorocyclopropyl)acetic acid | Ambeed | MFCD19229279 | 136.098 | C5H6F2O2 | 98.000 | OC(=O)CC1CC1(F)F | 250mg | 586036891
2-(2,2-Difluorocyclopropyl)acetic acid | Ambeed | 123131-67-9 | MFCD19229279 | 136.098 | C5H6F2O2 | 98.000 | OC(=O)CC1CC1(F)F | 250mg | 586036891
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eMolecules 64142-23-0 | 1-(4-Hydroxy-3-methoxyphenyl)butan-1-one | 250mg
Ambeed | 1-(4-Hydroxy-3-methoxyphenyl)butan-1-one | 250mg | 600826632 | A102410 | 64142-23-0 | 194.230 | C11H14O3
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eMolecules Building Block Tool<|a>
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eMolecules 50270-27-4 | 2,4,6-Trichloro-5-pyrimidinecarboxaldehyde | Accela ChemBio (ASD) | MFCD02257700 | 211.430 | C5HCl3N2O | 97.000 | Clc1nc(Cl)c(C=O)c(Cl)n1 | 10g | 532078938
2,4,6-Trichloro-5-pyrimidinecarboxaldehyde | Accela ChemBio (ASD) | 50270-27-4 | MFCD02257700 | 211.430 | C5HCl3N2O | 97.000 | Clc1nc(Cl)c(C=O)c(Cl)n1 | 10g | 532078938
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Ambeed AMBEED
5000847787 CEMMEC13 250MG
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Medchemexpress LLC Dagrocorat (PF-00251802) | 1044535-52-5 | 99.9% | 494.55 g/mol | C29H29F3N2O2 | 10 MG
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Dagrocorat (PF-00251802) is an orally active, selective, high-affinity partial agonist of the glucocorticoid receptor supplied for research use. It exhibits time-dependent reversible inhibition of CYP3A and inhibitory activity against CYP2D6, and is used in preclinical studies of inflammatory conditions such as rheumatoid arthritis.
- Orally active glucocorticoid receptor partial agonist useful for mechanistic studies.
- Shows time-dependent reversible inhibition of CYP3A and inhibits CYP2D6 (IC50/Ki values reported).
- High chemical purity (99.9%) suitable for research applications.
- Provided in small research quantities (10 MG) for laboratory use.
- Solid form with reported solubility in common organic solvents; follow supplier documentation for handling.
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